Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability
نویسندگان
چکیده
منابع مشابه
Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability.
Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their fu...
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ژورنال
عنوان ژورنال: Advanced Materials
سال: 2013
ISSN: 0935-9648
DOI: 10.1002/adma.201204346